Detergents

Ocular irritation test on reconstructed corneal epithelium

Regulatory reference:	OECD n° 492
Claim:	Non-irritant for the eyes
Application field:	Chemical substances or mixtures.
Description of the test:	Identification of chemical substances or mixtures that do not require classification as (severe) irritants through evaluation of their cytotoxic effects on an in vitro reconstructed corneal epithelium model. NOTE: if the sample qualifies as irritant, further tests are required in order to determine the degree of irritant action.

Posted in Cosmetic raw materials, Detergents, Make up, Claim for cosmetics, Non-irritant for the eyes

Eye tolerability test

Regulatory reference:	Guidelines to Commission Regulation (EU) No 655/2013
Claim:	Ophthalmologically tested
Application field:	Children shampoos and body washes.
Description of the test:	Ophthalmology experts evaluate the conditions of the eye surface and periocular region before and after 5 and 60 minutes of application of the diluted product. Self-evaluation of itching, burning, and irritaiton feeling.

Posted in Detergents, Claim for cosmetics, Ophthalmologically tested

In vitro short term exposure test

Regulatory reference:	OECD n° 491
Claim:	Non-irritant for the eyes (CLP Labelling)
Application field:	Raw ingredients or finished products.
Description of the test:	Short term exposure analysis by application of each tested substance on SIRC (Statens Seruminstitut Rabbit Cornea) cells for the determination of the effect on cell viability through MTT test.

Posted in Cosmetic raw materials, Detergents, Non-irritant for the eyes (CLP labelling), Make up, Moisturizers, Claim for cosmetics, Non-irritant for the eyes (CLP Labelling)

Skin irritation test on 3D reconstructed epidermis

Regulatory reference:	OECD n° 439
Claim:	Non-irritant for the skin
Application field:	Chemical substances or mixtures.
Description of the test:	Evaluation of the irritation potential of chemical substances or mixtures through evaluation of their cytotoxic effect on an in vitro reconstructed model of human skin.

Posted in Cosmetic raw materials, Detergents, Make up, Moisturizers, Claim for cosmetics, Non-irritant for the skin

Quantification of the titer of substances

Regulatory reference:	Regulation 1223/209
Claim:	Titer of substances and Limit of preservatives
Application field:	Preservatives, dyes, sunscreen filters.
Description of the test:	Quantification method for the measurement of the titer of substances by HPLC, UPLC, GC-MS after preparative steps.

Posted in Heating and cooling products, Mucoadhesive products, Cosmetic raw materials, Raw materials for medical devices, Detergents, Substance-based, Surgical devices and medications, Claim for cosmetics, Claim for medical devices, Titer of substances, Limit of preservatives

Evaluation of bacterial adhesion on mammal cells

Regulatory reference:	Proprietary method
Claim:	Inhibition of bacterial adhesion
Application field:	Medical devices design to inhibit bacterial adhesion.
Description of the test:	Evaluation of bacterial adhesion on mammal cells, performed on the CACO-2 cell line.

Posted in Protection and barrier effect, Detergents, Claim for cosmetics, Claim for medical devices, Inhibition of bacterial adhesion

Challenge Test

Regulatory reference:	ISO 11930 for cosmetics; European Pharmacopoeia for medical devices
Claim:	Efficacy of preservatives
Application field:	Cosmetics and medical devices.
Description of the test:	Challenge test for the evaluation of the efficacy of preservative systems according to ISO guidelines (for cosmetics) and European Pharmacopoeia (for medical devices).

Posted in Condom and vaginal products, Fabrics, plastics and polymer patches, Heating and cooling products, Mucoadhesive products, Protection and barrier effect, Detergents, Raw materials for medical devices, Substance-based, Surgical devices and medications, Make up, Moisturizers, Preservative systems, Claim for cosmetics, Claim for medical devices, Efficacy of preservatives